王梦竹;贾军峰;崔一喆;王秋菊;

• 1:黑龙江八一农垦大学动物科技学院
• 2:广东省农业科学院动物科学研究所农业部华南动物营养与饲料重点实验室

摘要(Abstract)：

脂多糖(LPS)是诱导肠黏膜损伤的应激源之一,其不仅可损伤肠道,还会引发细菌移位,损伤的胃肠道屏障会造成肠道紧密连接蛋白异常表达,使得内毒素、病原体等得以穿过肠壁,诱导活化细胞表面Toll样受体4(TLR4)激发下游的核因子-κB(NF-κB)信号通路,并合成释放细胞炎性因子,继而加重肠道的损伤。本文就LPS在诱导炎症反应发生的作用以及其潜在作用作一综述。

关键词(KeyWords)： LPS;TLR4;紧密连接蛋白;NF-κB

Abstract:

Keywords:

基金项目(Foundation): 黑龙江八一农垦大学研究生科研创新资助项目（YJSCX2018-Y35）;; 中国博士后科学基金会（第62批面上一等资助）（2017M620124）;中国博士后科学基金会（第十一批中国博士后科学基金特别资助）（2018T110320)

作者(Author): 王梦竹;贾军峰;崔一喆;王秋菊;

Email:

DOI:

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