脂多糖诱导的肠屏障蛋白及其信号通路研究进展Research Progress on Lipopolysaccharide-Induced Intestinal Barrier Signaling Pathway
王梦竹;贾军峰;崔一喆;王秋菊;
摘要(Abstract):
脂多糖(LPS)是诱导肠黏膜损伤的应激源之一,其不仅可损伤肠道,还会引发细菌移位,损伤的胃肠道屏障会造成肠道紧密连接蛋白异常表达,使得内毒素、病原体等得以穿过肠壁,诱导活化细胞表面Toll样受体4(TLR4)激发下游的核因子-κB(NF-κB)信号通路,并合成释放细胞炎性因子,继而加重肠道的损伤。本文就LPS在诱导炎症反应发生的作用以及其潜在作用作一综述。
关键词(KeyWords): LPS;TLR4;紧密连接蛋白;NF-κB
基金项目(Foundation): 黑龙江八一农垦大学研究生科研创新资助项目(YJSCX2018-Y35);; 中国博士后科学基金会(第62批面上一等资助)(2017M620124);中国博士后科学基金会(第十一批中国博士后科学基金特别资助)(2018T110320)
作者(Author): 王梦竹;贾军峰;崔一喆;王秋菊;
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